Safety and immunogenicity of four sequential doses of NVX-CoV2373 in adults and adolescents: a phase 3, randomized, placebo-controlled trial (PREVENT-19)

Publication date: Nov 10, 2024

Background NVX-CoV2373, a recombinant SARS-CoV-2 spike (rS) protein vaccine with Matrix-M adjuvant, has been authorized for use in adults and adolescents. PREVENT-19 (NCT04611802/2019nCoV-301), a pivotal phase 3, randomized, placebo-controlled trial demonstrated robust efficacy of a primary, 2-dose series of NVX-CoV2373 against COVID-19. Methods Protocol expansions to PREVENT-19 included enrollment of adolescents (aged 12 to

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Concepts Keywords
15042024_jn1_ure Cov
Gay Cov2373
German Covid
Vaccinated Dose
Editing
Https
Medrxiv
Novavax
Nvx
Preprint
Reviewing
Sars
Vaccine
Vaccines
Writing

Semantics

Type Source Name
disease IDO protein
disease MESH COVID-19
disease MESH Infectious Diseases
drug DRUGBANK Coenzyme M
disease IDO assay
disease MESH seroconversion
disease MESH urticaria
disease MESH breakthrough infection
disease IDO symptom
disease MESH infection
disease MESH complications
disease IDO replication
disease IDO country
disease MESH Allergy
disease MESH AIDS
drug DRUGBANK Carboxyamidotriazole
disease IDO blood
disease MESH emergency
drug DRUGBANK Adenosine 5′-phosphosulfate

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