Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014-2023 in Guangzhou, China.

Publication date: Nov 14, 2024

Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children. A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovirus and rotavirus A antigens in faeces. The epidemiological characteristics of these viruses and the impact of meteorological factors on them were analysed before and after coronavirus disease 2019 (COVID-19) pandemic. During this decade, the positive rate of adenovirus infection was 6. 41%, while the positive rate of rotavirus A infection was 11. 81%, higher than that of adenovirus infection. The positive rate of adenovirus and rotavirus A coinfection was 1. 92%. The positive rates of adenovirus, rotavirus A and coinfection showed a fluctuating trend, and suddenly decreased in 2020. There was an apparent decrease of positive rate of rotavirus A, with a decrease of 57. 27%, during 2020-2023. Surprisingly, the positive rate of adenovirus infection exceeded that of rotavirus A infection in 2021 and 2023. During the COVID-19 pandemic, the proportion of female patients and children over two years of age infected with adenovirus or rotavirus A increased, while the proportion of cases in winter decreased. In addition, we found that the positive rate of rotavirus A infection was related to average temperature and sunshine, and the positive rate of adenovirus and rotavirus A coinfection was only related to sunshine. However, these correlations disappeared during the COVID-19 pandemic. This study revealed the recent prevalence of adenovirus and rotavirus A infections in children with diarrhoea in south-central China and provided a theoretical basis for the prevention and control of viral diarrhoea.

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Concepts Keywords
Adenoviruses Adenovirus
China Children
Sunshine Diarrhoea
Meteorological factors
Rotavirus A
South-central China

Semantics

Type Source Name
disease MESH coinfection
disease MESH Infection
drug DRUGBANK Gold
disease MESH coronavirus disease 2019
disease MESH adenovirus infection
pathway REACTOME Reproduction
drug DRUGBANK Coenzyme M
disease MESH rotavirus infection
disease MESH death
disease IDO bacteria
disease IDO pathogen
drug DRUGBANK Nitazoxanide
disease IDO primary pathogen
disease MESH infectious diseases
disease IDO intervention
drug DRUGBANK Lactose
disease MESH intestinal obstruction
disease MESH bleeding
disease MESH pneumonia
disease MESH urinary tract infection
disease MESH gastroenteritis
disease IDO quality
drug DRUGBANK Etoperidone
disease MESH virus infections
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK Tretamine
drug DRUGBANK Ademetionine
pathway REACTOME Immune System
disease MESH reinfection
drug DRUGBANK Aspartame
disease IDO susceptibility
disease IDO infectivity
drug DRUGBANK Ethanol
drug DRUGBANK Rotavirus Vaccine
disease MESH missed diagnoses
disease IDO host
disease IDO zoonosis
disease MESH inflammation
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH dengue fever
disease MESH Respiratory infections
disease MESH Influenza
drug DRUGBANK Guanosine
drug DRUGBANK Troleandomycin
disease MESH Poliomyelitis
disease MESH community acquired infections
disease MESH norovirus infection

Original Article

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