Novel spin-lock time sampling strategies for improved reproducibility in quantitative T1ρ mapping.

Publication date: Dec 01, 2024

This study aimed to optimize the sampling of spin-lock times (TSLs) in quantitative T1ρ mapping for improved reproducibility. Two new TSL sampling schemes were proposed: (i) reproducibility-guided random sampling (RRS) and (ii) reproducibility-guided optimal sampling (ROS). They were compared to the existing linear sampling (LS) and precision-guided sampling (PS) schemes for T1ρ reproducibility through numerical simulations, phantom experiments, and volunteer studies. Each study evaluated the four sampling schemes with three commonly used T1ρ preparations based on composite and balanced spin-locking. Additionally, the phantom and volunteer studies investigated the impact of B and B field inhomogeneities on T1ρ reproducibility, respectively. The reproducibility was assessed using the coefficient of variation (CoV) by repeating the T1ρ measurements eight times for phantom experiments and five times for volunteer studies. Numerical simulations resulted in lower mean CoVs for the proposed RRS (1. 74%) and ROS (0. 68%) compared to LS (2. 93%) and PS (3. 68%). In the phantom study, the mean CoVs were also lower for RRS (2. 7%) and ROS (2. 6%) compared to LS (4. 1%) and PS (3. 1%). Furthermore, the mean CoVs of the proposed RRS and ROS were statistically lower (P 

Concepts Keywords
Biomed Adult
Mapping artifacts
Reproducibility Computer Simulation
Volunteer Female
Humans
Magnetic Resonance Imaging
Male
Phantoms, Imaging
quantitative MRI
reproducibility
Reproducibility of Results
Spin Labels
Spin Labels
spin‐lock
T1ρ
Time Factors

Original Article

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