Publication date: Nov 14, 2024
The optimal physiologic parameters to monitor after a session of awake prone positioning in patients with acute respiratory failure are not well understood. This study aimed to identify which early physiologic changes after the first session of awake prone positioning are linked to the need for invasive mechanical ventilation or death in patients with acute respiratory failure. We performed a secondary analysis of a prospective cohort study of adult patients with acute respiratory failure related to coronavirus disease 2019 (COVID-19) treated with awake prone positioning. We assessed the association between relative changes in physiological variables (oxygenation, respiratory rate, pCO and respiratory rate-oxygenation [ROX] index) within the first 6 h of the first awake prone positioning session with treatment failure, defined as endotracheal intubation and/or death within 7 days. 244 patients [70 female (29%), mean age 60 (standard deviation [SD] 13) years] were included. Seventy-one (29%) patients experienced awake prone positioning failure. ROX index was the main physiologic predictor. Patients with treatment failure had lower mean [SD] ROX index at baseline [5 (1. 4) versus 6. 6 (2. 2), p
| Concepts | Keywords |
|---|---|
| 7days | COVID-19 |
| Coronavirus | Prone positioning |
| Death | Respiratory distress syndrome |
| Physiologic | Respiratory failure |
| Seventy |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | acute hypoxemic respiratory failure |
| disease | MESH | death |
| disease | MESH | coronavirus disease 2019 |
| disease | MESH | treatment failure |
| disease | MESH | Respiratory distress syndrome |