Antiviral immunity lassoed down by excess RNA.

Publication date: Jan 06, 2025

Two complementary works by Chan et al. (https://doi. org/10. 1084/jem. 20231725), and Ru et al. (https://doi. org/10. 1084/jem. 20240010), identify defective RNA processing as the root cause of impaired antiviral immunity against SARS-CoV2 in the human brainstem. These studies provide molecular insight into virus-associated severe brainstem encephalitis through PKR inactivation.

Concepts Keywords
Antiviral Animals
Chan Brain Stem
Encephalitis COVID-19
Rna eIF-2 Kinase
eIF-2 Kinase
Humans
RNA, Viral
RNA, Viral
SARS-CoV-2

Semantics

Type Source Name
disease MESH encephalitis
disease MESH COVID-19

Original Article

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