Publication date: Nov 30, 2024
The patients with kidney failure who undergo maintenance hemodialysis (MHD) at high risk of morbidity and mortality from COVID-19. Previous studies showed that inflammation plays an important role in the progression of COVID-19. This study aimed to evaluate the prognostic value of the inflammatory indices in MHD patients with COVID-19. We included 141 patients receive MHD in this single-center. SARS-CoV-2 infection was confirmed by a positive result in RT-PCR analysis of nasal and pharyngeal swab samples, and the demographic, clinical, and laboratory data from December 1, 2022, to January 31, 2023 were reviewed. Inflammatory indices including PLR, NLR and SII were calculated. Binary logistics regression was used to examine the association between inflammatory indices and SARS-CoV-2 infection in MHD patients. The ROC curves were used to detect the sensitivity and specificity of these inflammatory indices in prediction of SARS-CoV-2 infection status in MHD patients. SARS-CoV-2 infection was detected in 76. 43 % of the 141 MHD patients. Lymphocyte (LY), aspartate transaminase (AST), blood urea nitrogen (BUN), uric acid (UA), PLR, NLR and SII were significant predictors of no SARS-CoV-2 infection and symptomatic SARS-CoV-2 infection. In addition, LY, serum ferritin (SF), AST, BUN, UA, PLR and NLR were significant predictors of asymptomatic SARS-CoV-2 infection and symptomatic SARS-CoV-2 infection. The ROC curves showed the best sensitivity and specificity of PLR (66. 7 % sensitivity; 68. 8 % specificity) and NLR (51. 9 % sensitivity; 86. 3 % specificity) in predicting symptomatic SARS-CoV-2 infection. PLR and NLR can be used as simple and inexpensive biomarkers in predicting the prognosis of COVID-19 in MHD patients.
Open Access PDF
| Concepts | Keywords |
|---|---|
| Covid | COVID-19 |
| Hemodialysis | Inflammation |
| Inflammatory | Maintenance hemodialysis |
| Kidney | Neutrophil/lymphocyte ratio |
| Platelet/lymphocyte ratio |