Second phase Chiba study of mother and child health (C-MACH): Japanese birth cohort study with multiomics analyses.

Publication date: Dec 09, 2024

Epidemiological studies have reported that environmental factors from fetal period to early childhood can influence the risk of non-communicable diseases in adulthood. This concept has been termed the developmental origins of health and disease (DOHaD). The Chiba study of Mother and Child Health (C-MACH) is a DOHaD concept-based birth cohort study which started in 2014. This study aims to investigate the effects of genetic and environmental factors, particularly fetal and postnatal living environment, on children’s health. We also aim to identify candidate biomarkers for their health status. Moreover, the second phase study of C-MACH which was initiated in 2021 aimed at expanding the sample size, especially for gut microbiota and epigenomic analysis; it also aimed at clarifying the impact of the coronavirus disease 2019 (COVID-19) pandemic on children’s health. This study consists of four hospital-based cohorts. Women who were

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Concepts Keywords
Biomarkers Adult
Coronavirus Biomarkers
Expanding Biomarkers
Japanese Birth Cohort
Mother Child
Child Health
Child, Preschool
Cohort Studies
COVID-19
COVID-19
East Asian People
Family
Female
Gastrointestinal Microbiome
GENETICS
Humans
Infant
Infant, Newborn
Japan
Male
Maternal Health
Multiomics
NEONATOLOGY
Observational Study
Paediatric endocrinology
Pregnancy
SARS-CoV-2

Semantics

Type Source Name
disease MESH non-communicable diseases
disease MESH health status
disease MESH coronavirus disease 2019

Original Article

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