STUDY to EVALUATE the ROLE of T CELL-DYSFUNCTION in SYMPTOMS ASSOCIATED with LONG COVID, LYME DISEASE and MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME USING the VIRAXIMMUNE FLUOROSPOT T CELL ASSAY

Publication date: Dec 11, 2024

This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS. The study will be a multi-centre study, with up to 160 male and female participants enrolled. Participants that experience symptoms considered to be associated with a diagnosis of long COVID, PTLDS or ME/CFS will consent to the study, and attend for two study visits (at study entry and 6 months) to complete a questionnaire related to their symptoms, and to have a blood sample taken. Blood samples will be taken either at the clinical site or at the participant’s home if they are unable to attend due to the severity of their illness. . Participants will be allocated to one of the following groups: Group 1: Long COVID Group 2: ME/CFS Group 3: PTLDS Group 4: Healthy Control

Concepts Keywords
Chemotherapy Cfs
Enrolment Chronic
Fluorospot Clinical
Infection4 Covid
Months Diagnosis
Evaluate
Fatigue
Group
Inflammatory
Long
Participants
Ptlds
Questionnaire
Study
Symptoms

Semantics

Type Source Name
disease IDO role
disease IDO cell
disease MESH LONG COVID
disease MESH LYME DISEASE
disease MESH MYALGIC ENCEPHALOMYELITIS
disease IDO assay
disease IDO blood
disease IDO site
disease IDO history
disease MESH COVID-19
disease MESH infection
disease MESH shortness of breath
disease MESH joint pain
drug DRUGBANK Ibuprofen
drug DRUGBANK Diclofenac
drug DRUGBANK Acetylsalicylic acid
disease MESH cognitive impairment
disease MESH inflammatory bowel disease
pathway KEGG Inflammatory bowel disease
disease MESH COPD

Original Article

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