Advancing the understanding of autoimmune/inflammatory syndrome induced by adjuvants (ASIA): Global research trends, key themes, and emerging frontiers.

Advancing the understanding of autoimmune/inflammatory syndrome induced by adjuvants (ASIA): Global research trends, key themes, and emerging frontiers.

Publication date: Jan 03, 2025

This study investigates global research on autoimmune/inflammatory syndrome induced by adjuvants (ASIA) to address gaps in disciplinary trends, research directions, and emerging topics, aiming to enhance understanding of ASIA’s role in immune dysregulation and multi-system diseases. This study uses bibliometric methods, based on data from the Web of Science (WOS) database, to analyze 203 ASIA-related publications from 2011 to 2024. Analytical tools, including VOSviewer, CiteSpace, and the bibliometrix R package, were employed to identify key research directions and frontier topics. Contributions from 40 countries, 318 institutions, and 824 researchers were analyzed, providing a global perspective on ASIA research. Israel contributed the highest publication volume, with Tel Aviv University being the most prolific contributor. Analysis showed that Immunologic Research published the most ASIA-related articles, whereas the Journal of Autoimmunity had the highest citation count. Keyword analysis identified six main research themes, including vaccine and adjuvant components, silicone implant-associated diseases, and connections between specific vaccines and autoimmune conditions. Thematic mapping highlighted key yet under-explored areas, such as immune responses to COVID-19 and HPV vaccines, and responses to specific adjuvants, offering insights into ASIA’s complexity. This study provides a comprehensive analysis of ASIA’s core themes and trends, highlighting key areas for future research, especially on the immune effects of vaccine adjuvants and implants. Although relying on a single data source, WOS’s extensive coverage and citation tracking support the validity of these findings, laying a foundation for future ASIA research and clinical applications.

Concepts Keywords
Asia Adjuvants
Bibliometrix Adjuvants, Immunologic
Inflammatory Adjuvants, Immunologic
Silicone ASIA syndrome
Vaccine Autoimmune Diseases
Bibliometrics
Bibliometrics analysis
Biomedical Research
Frontier topics
Humans
Inflammation
Research directions

Semantics

Type Source Name
disease MESH syndrome
disease IDO role
disease MESH Autoimmunity
disease MESH COVID-19
disease MESH data source
disease MESH Autoimmune Diseases
disease MESH Inflammation

Original Article

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