Publication date: Dec 18, 2024
SARS-CoV-2 mRNA vaccine reactogenicity has raised concerns regarding the risk of rejection in solid organ transplant recipients. We explored whether SOT recipients diagnosed with acute rejection had previously received a vaccine injection within a timeframe consistent with a causal link. We identified all SOT recipients with a diagnosis of acute rejection from 2020 to 2022 and who had previously received a SARS-CoV-2 vaccination, and analysed whether the delay between vaccination and rejection was constant. In the 45 identified patients, median delay between the last SARS-CoV-2 vaccination and the rejection was 102 days [IQR 48-178]; the continuous distribution of this delay, with no identifiable time pattern, is not in favor of a role of vaccination in rejection. SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.
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Concepts | Keywords |
---|---|
102days | Covid-19 |
Covid | Rejection |
Organ | SARS-CoV-2 |
Rejection | Solid-organ transplantation |
Vaccine | Vaccin |
Semantics
Type | Source | Name |
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disease | MESH | Covid-19 |
disease | IDO | role |