COVID-19 Diagnosis within 6 Weeks of Arthroscopic Knee Surgery Leads to Higher Risk for Post-operative Venous Thromboembolism.

COVID-19 Diagnosis within 6 Weeks of Arthroscopic Knee Surgery Leads to Higher Risk for Post-operative Venous Thromboembolism.

Publication date: Dec 19, 2024

To determine if pre-operative infection with COVID-19 increased risk for post-operative venous thromboembolism (VTE) in patients undergoing arthroscopic knee surgery. . PearlDiver Mariner 165 database was queried for patients undergoing knee arthroscopy between 2010 through October, 2022. Patients were categorized by history of COVID-19 diagnosis and timing in relation to surgery. Multivariate logistic regression was performed to isolate the effect of COVID-19 diagnosis on post-operative VTE rates. Covariates included age, obesity, smoking, oral contraceptive pill use, hypertension, coronary artery disease, congestive heart failure, malignancy, renal disease and diabetes. A total of 954,294 patients met inclusion criteria and 7,637 patients experienced VTE, including deep vein thrombosis (n = 5,830, 0. 61%) and pulmonary embolism (n=2,790, 0. 29%). Patients with a COVID-19 diagnosis prior to surgery (7,858) had an overall higher incidence of VTE (1. 72%) compared to patients without a pre-operative COVID-19 diagnosis (0. 81%) (p < 0. 001). There was no difference in VTE incidence amongst patients with a pre-operative COVID-19 diagnosis undergoing knee arthroscopy in the pre- and post-COVID-vaccination eras (OR 0. 82, 95% CI = 0. 51 - 1. 31, p=0. 48). Multivariate regression accounting for covariates showed that patients with a pre-operative COVID-19 diagnosis within 6 weeks before arthroscopy had significantly increased odds of experiencing post-operative VTE (OR 1. 68, 95% CI 1. 09-2. 45, p=0. 012). There was no significant difference in VTE risk between patients with a pre-operative COVID-19 diagnosis between 6-12 weeks before arthroscopy and more than 12 weeks before arthroscopy compared to those with no prior COVID-19 diagnosis. COVID-19 diagnosis within 6 weeks preceding arthroscopic knee surgery leads to a significantly higher risk for postoperative VTE. III, retrospective case control study.

Concepts Keywords
Diabetes Arthroscopic
October Arthroscopy
Pearldiver Covid
Surgery Diagnosis
Weeks Higher
Knee
Leads
Operative
Post
Pre
Risk
Surgery
Undergoing
Vte
Weeks

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Venous Thromboembolism
disease MESH infection
disease IDO history
disease MESH obesity
disease MESH hypertension
disease MESH coronary artery disease
disease MESH congestive heart failure
disease MESH malignancy
drug DRUGBANK Methionine
disease MESH deep vein thrombosis
disease MESH pulmonary embolism

Original Article

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