Increased Early-Mortality in Children With Solid Tumors During the COVID-19 Pandemic in a Middle-Income Country.

Increased Early-Mortality in Children With Solid Tumors During the COVID-19 Pandemic in a Middle-Income Country.

Publication date: Dec 01, 2024

Measures to control COVID-19 transmission disrupted childhood cancer care. Data on the effects of the COVID-19 pandemic on childhood cancer mortality are lacking. This study describes the impact of the pandemic on childhood cancer early-mortality (≤ 24 months). A multicenter prospective cohort was conducted in 10 Colombian cities. Children with newly diagnosed cancer registered in the Childhood Cancer Clinical Outcomes Surveillance System (VIGICANCER) were included. Our primary outcome was cumulative mortality at 3, 6, 12, and 24 months. The exposed cohort (EC = March 25, 2020-December 31, 2021) was compared with a historic cohort (HC = January 1, 2017-March 24, 2020). Covariates included sociodemographics, place of residence, health insurance type, and tumor classification. The cohort included 4124 children, comprised of 1627 children in the EC and 2497 children in the HC. Hematolymphoid, central nervous system, and extracranial solid tumors represented 57%, 15%, and 28% of patients, respectively. Participants’ median age was 6. 7 years (IQR, 3. 2-11. 3), 54% were male, 7% were Afro-descendant, and 47% had public insurance. In the EC, the 6-month and 24-month mortality adjusted hazard ratio (aHR) in children with solid tumors was 1. 7 (95% CI, 1. 1-2. 7) and 1. 3 (95% CI, 1. 0-1. 7), respectively, and in children with bone tumors 4. 0 (95% CI, 1. 2-13. 0) and 2. 1 (95% CI, 1. 2-3. 6), respectively. These associations persisted after accounting for metastatic disease. Six-month mortality aHRs for retinoblastoma, bone tumors, and soft tissue sarcomas due to progressive disease were 4. 3 (95% CI, 1. 3-14. 5), 4. 0 (95% CI, 1. 4-11. 3), and 5. 4 (95% CI, 2. 2-13. 5), respectively. In the EC, the adjusted odds ratio (aOR) for metastatic solid tumors vs. nonmetastatic was 1. 4 (95% CI, 1. 0-1. 8) and in children with retinoblastoma and public insurance the 24-month mortality aHR was 4. 9 (95% CI, 1. 1-21. 7). We observed increased early-mortality for solid tumors, particularly bone tumors and retinoblastoma, likely attributed to more advanced-stage presentation and loss of treatment effectiveness due to healthcare disruptions. Early-mortality was higher in patients with public insurance, a vulnerable population that warrants attention.

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Concepts Keywords
Afro bone neoplasms
Colombian Child
Pandemic Child, Preschool
Stage Colombia
COVID-19
COVID‐19
epidemiological monitoring
Female
hospital
Humans
Infant
Male
mortality
Neoplasms
neoplasms
oncology service
pediatrics
Prospective Studies
retinoblastoma
SARS-CoV-2

Semantics

Type Source Name
disease MESH Tumors
disease MESH COVID-19 Pandemic
disease IDO country
disease MESH retinoblastoma
disease MESH soft tissue sarcomas
disease MESH bone
drug DRUGBANK Coenzyme M
pathway REACTOME Reproduction
disease MESH infection
drug DRUGBANK Stavudine
drug DRUGBANK Tretamine
disease MESH craniopharyngioma
disease MESH death
disease MESH relapse
drug DRUGBANK Trestolone
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK Cysteamine
drug DRUGBANK Methionine
drug DRUGBANK L-Valine
disease MESH central nervous system tumors
disease MESH Leukemias
disease MESH Lymphomas
disease MESH Neuroblastoma
disease MESH melanomas
disease MESH metastasis
disease MESH long COVID
disease MESH hematological malignancies
drug DRUGBANK Aspartame
drug DRUGBANK Etoperidone
drug DRUGBANK Angelica archangelica root
disease MESH privacy
drug DRUGBANK Esomeprazole
disease IDO blood
disease MESH Psychological Distress
disease IDO process
drug DRUGBANK Adenosine
drug DRUGBANK Guanosine
disease MESH Chronic Diseases
disease MESH TIC
drug DRUGBANK Methyl isocyanate

Original Article

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