Exploring optimal control strategies in a nonlinear fractional bi-susceptible model for Covid-19 dynamics using Atangana-Baleanu derivative.

Publication date: Dec 30, 2024

In this article, a nonlinear fractional bi-susceptible [Formula: see text] model is developed to mathematically study the deadly Coronavirus disease (Covid-19), employing the Atangana-Baleanu derivative in Caputo sense (ABC). A more profound comprehension of the system’s intricate dynamics using fractional-order derivative is explored as the primary focus of constructing this model. The fundamental properties such as positivity and boundedness, of an epidemic model have been proven, ensuring that the model accurately reflects the realistic behavior of disease spread within a population. The asymptotic stabilities of the dynamical system at its two main equilibrium states are determined by the essential conditions imposed on the threshold parameter. The analytical results acquired are validated and the significance of the ABC fractional derivative is highlighted by employing a recently proposed Toufik-Atangana numerical technique. A quantitative analysis of the model is conducted by adjusting vaccination and hospitalization rates using constant control techniques. It is suggested by numerical experiments that the Covid-19 pandemic elimination can be expedited by adopting both control measures with appropriate awareness. The model parameters with the highest sensitivity are identified by performing a sensitivity analysis. An optimal control problem is formulated, accompanied by the corresponding Pontryagin-type optimality conditions, aiming to ascertain the most efficient time-dependent controls for susceptible and infected individuals. The effectiveness and efficiency of optimally designed control strategies are showcased through numerical simulations conducted before and after the optimization process. These simulations illustrate the effectiveness of these control strategies in mitigating both financial expenses and infection rates. The novelty of the current study is attributed to the application of the structure-preserving Toufik-Atangana numerical scheme, utilized in a backward-in-time manner, to comprehensively analyze the optimally designed model. Overall, the study’s merit is found in its comprehensive approach to modeling, analysis, and control of the Covid-19 pandemic, incorporating advanced mathematical techniques and practical implications for disease management.

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Concepts Keywords
Coronavirus ABC operator
Efficient Computer Simulation
Hospitalization COVID-19
Mathematical Humans
Pandemic Models, Theoretical
Nonlinear Dynamics
optimal control
Pandemics
SARS-CoV-2
sensitivity
stability
Toufik-Atangana

Semantics

Type Source Name
disease MESH Covid-19
pathway KEGG Coronavirus disease
drug DRUGBANK Abacavir
disease IDO process
disease MESH infection
disease IDO history
disease MESH pneumonia
drug DRUGBANK Coenzyme M
disease MESH unemployment
disease MESH sore throat
disease MESH chest pain
disease MESH confusion
disease MESH emergency
disease MESH complications
disease MESH hypertension
disease MESH respiratory infections
disease MESH infectious diseases
disease IDO intervention
disease MESH privacy
drug DRUGBANK Tropicamide
disease IDO susceptibility
disease IDO susceptible population
disease IDO immune response
pathway REACTOME Infectious disease
disease IDO infectious disease
disease IDO host
disease MESH heart disease
disease IDO infected population
drug DRUGBANK Isoxaflutole
pathway REACTOME Reproduction
disease MESH virus infections
disease IDO infectivity
disease MESH aids
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH death
drug DRUGBANK Phosmet
disease IDO diseased population
drug DRUGBANK Stanolone
disease IDO algorithm
disease MESH Amelia
disease MESH heart attack
disease MESH critically ill
disease MESH Middle East respiratory syndrome
disease MESH tumor
pathway REACTOME Immune System
disease MESH Tuberculosis
pathway KEGG Tuberculosis
disease MESH measles
pathway KEGG Measles
disease MESH diabetes mellitus
disease MESH malaria
pathway KEGG Malaria
disease MESH co infection
disease MESH pneumococcal pneumonia
disease MESH meningitis
disease MESH monkeypox
disease MESH viral load
disease MESH dengue fever
drug DRUGBANK Sulpiride
disease IDO quality

Original Article

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