Association of SARS-CoV-2 Infection during pregnancy with placental weight and histopathologic lesions.

Association of SARS-CoV-2 Infection during pregnancy with placental weight and histopathologic lesions.

Publication date: Dec 25, 2024

The reported gross and histopathologic changes in the placenta associated with SARS-CoV-2 infection are heterogeneous. We sought to summarize placental histopathologic findings from pregnancies affected by SARS-CoV-2 infection according to timing of infection and symptom severity. We conducted a retrospective cohort study of patients with SARS-CoV-2 infection during pregnancy who had deliveries at Mayo Clinic, Rochester, Minnesota, from April 2020 through June 2021. Placental histopathologic findings and clinical characteristics were compared for infections before vs after 28 weeks’ gestation and according to COVID-19 symptom severity. We analyzed 93 cases of SARS-CoV-2 infection during pregnancy, with 51 % of infections occurring before 28 weeks’ gestation. Infections were categorized as asymptomatic (14 %), mild (77 %), moderate (6 %), and severe (3 %) according to World Health Organization criteria. An increased risk of small placental weight (

Concepts Keywords
April COVID-19
Clinic Placenta
Histopathologic Placentitis
Minnesota Pregnancy
Pregnancy SARS-CoV-2

Semantics

Type Source Name
disease MESH SARS-CoV-2 Infection
pathway REACTOME SARS-CoV-2 Infection
disease MESH infection
disease IDO symptom

Original Article

(Visited 1 times, 1 visits today)