Publication date: Jan 03, 2025
To evaluate the effects of different SARS-CoV-2 inactivation methods on the blood concentration of colistin sulfate. A colistin sulfate reference substance, a quality control plasma sample, and a clinically measured sample were transferred and heated in a 56 ^0C water batch for 30 min or irradiated under an ultraviolet (UV) lamp for 60 min to examine the stability of the reference solution and quality control plasma sample. Statistical analysis was conducted for the concentration of the clinically measured sample before and after inactivation with the intraclass correlation coefficient (ICC) method, the Passing-Bablok regression, and the Bland-Altman analysis. The reference substance of colistin sulfate was unstable under UV inactivation. Under moist heat inactivation, the reference substance and quality control plasma sample of colistin sulfate were stable. The ICC of the concentration results of 27 clinical blood samples with and without moist heat inactivation was 0. 995 (P
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| Concepts | Keywords |
|---|---|
| 30min | Colistin sulfate |
| Bland | Plasma concentration |
| Blood | SARS-CoV-2 |
| Colistin | Therapeutic drug monitoring |
| Plasma | Virus inactivation |