Publication date: Jan 09, 2025
Respiratory tract infections (RTIs) caused by bacteria or viruses are associated with stroke severity. Recent studies have revealed an imbalance in the von Willebrand factor (VWF)-ADAMTS13 axis in patients with RTIs, including COVID-19. We examined whether this imbalance contributes to RTI-mediated stroke severity. Wild-type (WT), Vwf -/-, or Adamts13-/- mice with respective littermate controls (Vwf +/+, or Adamts13+/+) were infected intranasally with sublethal doses of S. aureus (on days 0, 2, and 5) or mouse-adapted SARS-CoV-2 (on day 0) and subjected to transient (30 or 45 min) cerebral ischemia followed by reperfusion. In S. aureus-infected mice, infarct volumes were assessed on day 2 and functional outcomes on weeks 1 and 4 post-reperfusion. In SARS-CoV-2-infected mice, infarct volumes and functional outcomes (Bederson score) were assessed on day 1 post-reperfusion. We demonstrated that S. aureus or SARS-CoV-2 RTI was accompanied by an imbalance in the VWF-ADAMTS13 axis and an increase in plasma levels of IL-6, CXCL1, and MCP-1, which was associated with larger infarcts and worse functional outcomes (P
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| Concepts | Keywords |
|---|---|
| Adamts13 | Adamts13 |
| Day | Aureus |
| Mice | Axis |
| Reperfusion | Contributes |
| Viruses | Cov |
| Day | |
| Functional | |
| Imbalance | |
| Infected | |
| Outcomes | |
| Reperfusion | |
| Respiratory | |
| Sars | |
| Stroke | |
| Vwf |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | respiratory tract infection |
| disease | MESH | stroke |
| disease | IDO | bacteria |
| drug | DRUGBANK | Von Willebrand Factor Human |
| disease | MESH | COVID-19 |
| disease | MESH | cerebral ischemia |
| disease | MESH | infarct |
| disease | IDO | blood |