Attributes and factors associated with long covid in patients hospitalized for acute COVID-19: A retrospective cohort study.

Publication date: Jan 17, 2025

It is now recognized that many patients have persistent symptoms after recovery from acute COVID-19 infection, an infection caused by the coronavirus SARS-CoV-2. This constellation of symptoms known as ‘Long COVID’ may manifest with a wide range of physical and cognitive/psychological symptoms. Few data are available on the prevalence, attributes, and factors associated with Long COVID in Africa. This was a retrospective review of patients’ electronic medical records from Hallelujah General Hospital (one of the first private hospitals to treat COVID-19 patients). The hospital’s database was searched for patients hospitalized for acute COVID-19 infection from March 2020 to December 2022. Two hundred and forty-seven participants who underwent follow-up beginning four weeks after symptom onset were assessed for Long COVID. Admission and follow-up data were collected using Kobo Toolbox and exported into SPSS 27 for analysis. The relationship between the independent and dependent variables was explored through binary logistic regression. One hundred seventy-eight (72. 1%) participants had at least one persisting symptom 4 weeks post-symptom onset, at a median follow-up time of 35 (IQR 32-40) days. The most frequently reported symptoms were fatigue (41. 7%), shortness of breath (31. 2%), cough (27. 1%), and sleep disturbances (15%). Duration of symptoms more than 7 days before admission [aOR = 1. 97; CI95% = 1. 04 to 3. 75; P = 0. 038] and length of stay more than 10 days in the hospital [aOR = 2. 62; CI95% = 1. 20 to 5. 72; P = 0. 016] were found to be significantly associated with Long COVID. There is a high prevalence of Long COVID among patients hospitalized for acute COVID-19. Those who had a longer duration of symptoms before admission and a longer stay in the hospital appear to have a higher risk.

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Concepts Keywords
Africa Adult
Coronavirus Aged
December COVID-19
Hospitals Female
Toolbox Hospitalization
Humans
Male
Middle Aged
Post-Acute COVID-19 Syndrome
Retrospective Studies
Risk Factors
SARS-CoV-2

Semantics

Type Source Name
disease MESH long covid
disease MESH COVID-19
disease MESH infection
disease IDO symptom
disease MESH shortness of breath
drug DRUGBANK Niflumic Acid
drug DRUGBANK Coenzyme M
disease IDO history
disease IDO process
pathway REACTOME Reproduction
disease MESH sequelae
disease MESH syndrome
drug DRUGBANK Carbon monoxide
disease MESH fibrosis
disease MESH asthma
pathway KEGG Asthma
disease MESH hypertension
drug DRUGBANK Oxygen
disease MESH diabetes mellitus
drug DRUGBANK Tropicamide
disease MESH infectious diseases
drug DRUGBANK Methionine
disease MESH arthralgia
disease MESH Chest pain
disease MESH Anosmia
disease MESH Ageusia
disease MESH abnormalities
disease MESH Anemia
drug DRUGBANK Creatinine
disease MESH pneumonia
disease IDO protein
disease IDO blood

Original Article

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