Publication date: Jan 26, 2025

By designing a peptide that binds the drug while enhancing its solubility, we were able to create nanoparticles with very high loading. ” The nanoparticles are primarily composed of the drug, with a thin peptide coating that improves solubility, enhances stability in the body, and optimizes delivery to targeted areas. -. .. many drug-delivery systems do not exhibit high loading efficiency; often they are in the range of 5-10% drug by mass, which limits their potential efficacy. ” And while nanoparticles (NPs) can improve drug pharmacokinetics, low loading efficiencies can limit treatment efficacy, the investigators noted. Given the vast range of possible interactions in peptide design, it may be feasible to tailor peptides for specific drugs, extending their applicability beyond cancer treatments. Drug delivery systems often face two critical challenges: poor solubility and inefficient delivery within the body. For their reported study the research team developed a novel solution by designing peptides that bind with specific drugs to create therapeutic nanoparticles.

Semantics