Predictors of specialist care referrals (SCR) following emergency department review or hospital admission in adults with previous acute COVID-19: a prospective UK cohort study.

Publication date: Jan 23, 2025

Long-COVID research to date focuses on outcomes in non-hospitalised vs. hospitalised survivors. However Emergency Department attendees (post-ED) presenting with acute COVID-19 may experience less supported recovery compared to people admitted and discharged from hospital (post-hospitalised group, PH). We evaluated outcomes and predictors of specialty care referrals (SCR) in those with ongoing symptomatic Long-COVID, comparing post-ED and PH adults. This prospective observational cohort study evaluates 800 PH and 484 post-ED adults from a single hospital in London, United Kingdom. Participants had either confirmed laboratory-positive SARS-CoV-2 infection or clinically suspected acute COVID-19 and were offered post-COVID clinical follow-up at approximately six weeks after their ED attendance or inpatient discharge, to assess ongoing symptoms and support recovery. Multiple logistic regression determined associations with specialist care referrals (SCR) to respiratory, cardiology, physiotherapy (including chest physiotherapy), and mental health services. Presence of at least one Long-COVID symptom was lower in adults attending ED services with acute COVID-19 compared to those hospitalised (70. 1% post-ED vs. 79. 5% PH adults, p 

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Concepts Keywords
Attendees Adult
Inpatient Aged
London COVID-19
Weeks Emergency department
Emergency Service, Hospital
Female
Hospitalization
Humans
London
Long-COVID
Male
Middle Aged
Ongoing symptomatic COVID-19
Post-Acute COVID-19 Syndrome
Prospective Studies
Referral and Consultation
SARS-CoV-2
SARS-CoV-2
Specialization
United Kingdom

Semantics

Type Source Name
disease MESH emergency
disease MESH COVID-19
pathway REACTOME SARS-CoV-2 Infection
disease IDO symptom
pathway REACTOME Reproduction
disease MESH Long COVID
disease MESH infection
disease MESH symptom burden
drug DRUGBANK Esomeprazole
disease IDO blood
disease MESH mental illness
disease MESH morbidity
disease MESH ARC
drug DRUGBANK 3 7 11 15-Tetramethyl-Hexadecan-1-Ol
disease MESH breathlessness
disease MESH chest pain
disease MESH cardiac disease
disease MESH brain fog
disease MESH pneumonia
disease MESH dementia
disease MESH frailty
drug DRUGBANK Trestolone
drug DRUGBANK Coenzyme M
drug DRUGBANK Aspartame
drug DRUGBANK Serine
disease MESH Diabetes Mellitus
disease MESH Hypertension
disease MESH embolus
disease MESH Anorexia
disease MESH Anosmia
disease MESH Confusion
disease MESH Depressive symptoms
disease MESH comorbidity
drug DRUGBANK Methylergometrine
drug DRUGBANK Oxygen
disease IDO history
disease MESH acute disease
drug DRUGBANK Etoperidone
disease MESH anxiety
disease MESH psychotic disorders
disease MESH critically ill
drug DRUGBANK Elm

Original Article

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