Publication date: Jan 15, 2025

Background: To evaluate the impact of applying alternative diagnostic criteria for gestational diabetes mellitus (GDM) during the COVID-19 pandemic on GDM prevalence, obstetrical and perinatal outcomes, and costs, as compared to the standard diagnostic method. Methods: A cohort of pregnant individuals undergoing GMD screening with the alternative GDM method, which uses plasma glucose (fasting or non-fasting) and HbA1c, was compared with a cohort of pregnant individuals undergoing the standard GDM screening method. Both cohorts were obtained from six hospitals across Catalonia, Spain, from April 2020 to April 2022. The primary outcome was large for gestational age rate at birth. The secondary outcomes were composite adverse outcomes, including pregnancy complications, delivery complications, and neonatal complications. The cost differences between screening methods were also evaluated. A similar analysis was performed in the subgroup diagnosed with GDM. Results: Data were collected from 1543 pregnant individuals in the standard screening group and 2197 in the alternative screening group. The standard screening group had a higher GDM diagnostic rate than the alternative screening group (10. 8% vs. 6. 9%, respectively; p < 0. 0001). The primary outcome (large for gestational age rate) was similar between groups: 200/1543 (13. 0%) vs. 303/2197 (13. 8%). The adjusted OR for this outcome was 1. 74 (95% CI: 0. 74-4. 10). An adjusted analysis showed no differences between groups in the composite adverse outcomes for pregnancy complications (OR: 1. 11; 95% CI: 0. 91-1. 36), delivery complications (OR: 0. 95; 95% CI: 0. 75-1. 19), and neonatal complications (OR: 1. 28; 95% CI: 0. 94-1. 75). Among individuals diagnosed with GDM, the large for gestational age rate was similar between groups: 13/166 (7. 8%) vs. 15/151 (9. 9%). The OR adjusted for this outcome was 1. 24 (95% CI: 0. 51-3. 09). An adjusted analysis showed no differences in the composite adverse outcomes for pregnancy complications (OR: 1. 57; 95% CI: 0. 84-2. 98), delivery complications (OR: 1. 21; 95% CI: 0. 63-2. 35), and neonatal complications (OR: 1. 35; 95% CI: 0. 61-3. 04). The mean cost (which included expenses for consumables, equipment, and personnel) of the alternative screening method was 46. 0 euros (22. 3 SD), as compared to 85. 6 euros (67. 5 SD) for the standard screening method. Conclusions: In this Spanish population during the COVID-19 pandemic, GDM prevalence was lower in the alternative screening group than in the standard screening group. After adjusting for GDM risk factors, outcomes related to obstetrics, delivery, and neonatal complications were comparable between both groups. Finally, the alternative screening method was cheaper than the standard screening method.

Open Access PDF

Semantics

Original Article