Publication date: Jan 31, 2025

Older age and comorbidities are risk factors for increased coronavirus disease 2019 (COVID-19) severity, but few studies have explored their interaction. This study aimed to assess the actual impacts of these factors on disease severity in COVID-19. The enrolled COVID-19 patients were divided into 4 age subgroups (≤44, 45-59, 60-74, and ≥75 years). Logistic regression analysis was conducted to determine the association between comorbidities and disease severity; Kappa consistency test was implemented to verify the study results. Of the 1663 patients with COVID-19, 287 had severe disease. The disease severity was correlated with the age-adjusted Charlson Comorbidity Index in each age group. In the 4 subgroups, the odds ratio of age-adjusted Charlson Comorbidity Index declined with age. After removing age interference, diabetes and cardio-cerebrovascular diseases were the main risk factors for severe disease in patients aged

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