Small fiber neuropathy in the post-COVID condition and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical significance and diagnostic challenges.

Publication date: Feb 01, 2025

Patients with post-COVID condition (PCC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience symptoms potentially associated with small fiber neuropathy (SFN). A sample of 90 participants, comprising 30 PCC patients, 30 ME/CFS patients, and 30 healthy controls (HC), matched by sex and age, was assessed. Neuropathic, autonomic, and fatigue symptoms were measured with TaskForce Monitor, the Sudoscan, heat and cold evoked potentials, In Vivo Corneal Confocal Microscopy (IVCCM), and specialized questionaries. PCC and ME/CFS patients demonstrated significantly higher levels of autonomic symptoms (H = 39. 89, p

Concepts	Keywords
Cold	Adult
Drugs	Clinical Relevance
Encephalomyelitis	COVID-19
Matched	Fatigue Syndrome, Chronic
Pcc	Female
	Humans
	Male
	Middle Aged
	Post-Acute COVID-19 Syndrome
	post‐COVID condition
	Small Fiber Neuropathy
	small fiber neuropathy

Semantics

Type	Source	Name
disease	MESH	Small fiber neuropathy
disease	MESH	post-COVID condition
disease	MESH	Myalgic Encephalomyelitis
disease	MESH	Clinical significance
drug	DRUGBANK	Factor IX Complex (Human)
disease	MESH	COVID-19

Original Article

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