Successful Management of COVID-19-Associated Systemic Capillary Leak Syndrome Using Veno-Venous Extracorporeal Membrane Oxygenation: A Case Report.

Publication date: Dec 01, 2024

Systemic capillary leak syndrome (SCLS) is a rare and life-threatening disorder characterized by acute hypotension, hypoalbuminemia, and hemoconcentration, which often results in severe respiratory complications, such as pulmonary edema. SCLS can be triggered by infections, including COVID-19, and is associated with a high mortality rate. Here, we report a case of COVID-19-associated SCLS in a 68-year-old man. After aggressive fluid resuscitation, the patient’s respiratory failure worsened. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) was initiated early because of rapidly declining oxygenation (PaO/FiO=58) and pulmonary compromise. V-V ECMO successfully supported respiratory and circulatory functions and stabilized the patient. The patient was successfully weaned from ECMO on day 10 and later discharged from the ICU in stable condition. This case highlights the potential benefits of early ECMO intervention and controlled fluid resuscitation in managing COVID-19-associated SCLS.

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Concepts Keywords
Aggressive covid-19
Covid covid-19-associated scls
Hemoconcentration v-v ecmo
Mortality
Old

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Systemic Capillary Leak Syndrome
disease MESH hypotension
disease MESH hypoalbuminemia
disease MESH complications
disease MESH pulmonary edema
disease MESH infections
disease MESH respiratory failure
disease IDO intervention
pathway REACTOME Reproduction
drug DRUGBANK Coenzyme M
disease MESH Emergency
disease MESH Infectious Disease
pathway REACTOME Infectious disease
disease IDO history
disease IDO blood
drug DRUGBANK Oxygen
drug DRUGBANK Medical air
drug DRUGBANK Urea
drug DRUGBANK Nitrogen
drug DRUGBANK Creatinine
drug DRUGBANK Potassium
drug DRUGBANK Chloride ion
disease MESH hyperlactatemia
disease MESH heart failure
disease MESH septic shock
disease MESH atrial fibrillation
drug DRUGBANK Norepinephrine
drug DRUGBANK Vasopressin
disease MESH pleural effusion
disease MESH atelectasis
drug DRUGBANK Isoxaflutole
disease MESH upper respiratory tract infections
disease MESH hematologic malignancies
disease IDO infection
disease MESH edema
disease MESH severe sepsis
disease MESH cardiogenic shock
disease MESH shock
disease MESH multiple organ failure
disease MESH Allergy
pathway REACTOME Influenza Infection
drug DRUGBANK Ilex paraguariensis leaf

Original Article

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