Publication date: Mar 01, 2025

This meta-analysis aims to estimate temporal decline in vaccine-induced antibodies against severe acute respiratory syndrome coronavirus 2 up to 9 months after full vaccination contributing to overall understanding of coronavirus disease 2019 infection protection. We identified 15 eligible studies and calculated standardized mean differences (SMD) between antibody concentrations at 1, 3, 6, and 9 months after full vaccination. Overall SMD between 1 month after vaccination and 3 months was -1. 14 (95% CI -1. 52, -0. 76), at 6 months was -1. 06 (95% CI -1. 30, -0. 81), and at 9 months, it was -0. 77 (95% CI -0. 94, -0. 60) suggesting a moderate decline over time.

Semantics

Original Article