Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU.

Publication date: Feb 05, 2025

The aims of our study were to assess the correlations between sarcopenia and myosteatosis assessed by CT-scan at T4 and/or L3 levels and inflammation in critically ill COVID patients on ICU admission, and their respective prognostic value on day 90 death (D90-death). It is a retrospective monocentric study. Sarcopenia was defined by skeletal muscle cross sectional surface area (CSA) and myosteatosis by skeletal muscle density (SMD) at L3 and T4 levels. Inflammatory biomarkers were collected on ICU admission. Of the 239 patients, 74 died by D90; 66. 6% get sarcopenia on ICU admission. CSA at T4 level was an independent risk factor for D90-death (1. 66[1. 03; 2. 66]; p = 0. 04), as were procalcitonin (2. 03[1. 2; 3. 43]; p = 0. 01) and IL-6 levels (1. 56[0. 96; 2. 54]; p = 0. 07). In addition, we found correlation factors of 0. 79 (p 

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Concepts Keywords
Biomarkers Aged
Covid Biomarkers
Ct Biomarkers
Death Chest CT-scan
Pneumonia COVID 19
COVID-19
Critical Illness
Critical illness
Female
Humans
Inflammation
Inflammation
Intensive Care Units
Interleukin-6
Interleukin-6
Low muscle mass
Male
Middle Aged
Muscle, Skeletal
Outcome
Procalcitonin
Procalcitonin
Prognosis
Retrospective Studies
Risk Factors
Sarcopenia
Sarcopenia
SARS-CoV-2
Tomography, X-Ray Computed

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