Tomographic features of lung damage associate with D-Dimer levels and further clinical outcome in patients with acute respiratory distress syndrome due to COVID-19.

ingentiumby ingentium

In Discovery Literature.

Publication date: Feb 06, 2025

Rapid progression of symptoms and development of Acute Respiratory Distress Syndrome (ARDS) frequently occurred during COVID-19 pandemic, while CT-Scan was useful to assess severity of lung damage, with classic patterns like early Ground Glass Opacity and/or late consolidation. Likewise, lung injury has been related to activation of the coagulation-fibrinolysis systems and pro-inflammatory mediators; where D-Dimer acquires prognostic relevance. The present study aimed to evaluate whether the extent of lung involvement and pattern of lung injury, as determined by chest CT-scan, are related with D-Dimer; and further impact clinical prognosis in patients with ARDS due to COVID-19. Longitudinal, prospective, observational, multi-center study. Patients diagnosed with ARDS due to COVID-19, without previous lung damage, clotting disorder and/or anticoagulants use, who were attended at the Intensive Care Unit and Internal Medicine Department from March to June 2020. Tomographic extent of lung involvement was analyzed by image software, as well as damage patterns, assessed by experienced radiologists. Endpoints included relation of lung injury with coagulopathy markers like D-Dimer, and prognostic outcome including mortality, mechanical ventilation and hospitalization time. One-hundred and four patients mean aged 55 years old, 66% males, main comorbidities obesity, hypertension and diabetes mellitus. Larger lung damage was associated with older age, male gender and higher pro-inflammatory mediators like leukocytes and ferritin; whilst consolidation pattern was related to higher Body Mass Index. Higher values of D-Dimer were related either to a larger extent of lung involvement or late consolidation pattern. In addition, the extent of lung involvement was related with longer hospital stay, higher requirement of mechanical ventilation (HR 0. 12, p 

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Concepts Keywords
Hospitalization Acute respiratory syndrome
June Consolidation
Obesity COVID-19
Old CT-scan
Tomographic D-Dimer
Ground glass opacity
Lung injury

Semantics

Type Source Name
disease MESH acute respiratory distress syndrome
disease MESH COVID-19
disease MESH lung injury
disease MESH obesity
disease MESH hypertension
disease MESH diabetes mellitus
pathway REACTOME Reproduction
drug DRUGBANK Coenzyme M
disease MESH death
disease MESH infection
disease MESH multiple organ failure
disease MESH complications
disease MESH tic
disease MESH COPD
disease MESH asthma
pathway KEGG Asthma
disease MESH hemorrhage
disease MESH syndrome
disease MESH comorbidity
drug DRUGBANK Fenamole
drug DRUGBANK Trestolone
disease MESH Dyslipidemia
disease MESH Hypothyroidism
disease MESH Heart Disease
disease MESH Hyperplasia
disease MESH Breast Cancer
pathway KEGG Breast cancer
disease MESH Stroke
disease MESH edema
disease MESH inflammation
drug DRUGBANK Medical air
disease MESH fibrosis
disease IDO protein
disease MESH cytokine storm
drug DRUGBANK Sulodexide
disease MESH vasculitis
disease MESH hypoxia
drug DRUGBANK Oxygen
disease MESH thrombosis
disease MESH sepsis
disease MESH abnormalities
drug DRUGBANK Angiotensin II
disease MESH pulmonary edema
drug DRUGBANK Methylergometrine
disease MESH pneumonia
drug DRUGBANK Indoleacetic acid
disease MESH privacy
drug DRUGBANK Diethylstilbestrol
disease MESH severe Acute Respiratory Syndrome
disease MESH Middle East Respiratory Syndrome
drug DRUGBANK Sulfasalazine
disease MESH clinical course
disease MESH critically ill
disease IDO pathogen

Original Article

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