Publication date: Feb 05, 2025
The causal relationship between basal metabolic rate (BMR) and infectious diseases remains elusive. This study aims to clarify this association. This study analyzed genome-wide association studies (GWASs) data from the UK Biobank and FinnGen cohorts to investigate the association between BMR and infectious diseases in European populations. Mendelian randomization (MR) analysis was initially employed, followed by multivariable Mendelian randomization (MVMR) to account for potential confounders. Mediation analysis further confirmed significant relationships. Sensitivity analyses were conducted to validate the study findings. Using two sample MR, genetically predicted BMR was positively linked to skin and soft tissue infections (SSTIs) (OR: 1. 31, 95% CI: 1. 18-1. 47, P
| Concepts | Keywords |
|---|---|
| Biobank | basal metabolic rate |
| Elusive | infectious diseases |
| Mendelian | Mendelian randomization |
| Postgrad | osteomyelitis |
| Therapy |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | infectious diseases |
| disease | MESH | soft tissue infections |
| disease | MESH | osteomyelitis |