Publication date: Feb 06, 2025
In this study, we examine the association between COVID-19 vaccination and antibody titer and whether this association varies by nutritional status and duration of school attendance using linear regression models applied to seven-year-old children from the 2015 Pelotas (Brazil) Birth Cohort (n = 2956). Antibody titers were 0. 29 optical density (OD) titer units higher among vaccinated compared with unvaccinated children (95 % CI: 0. 24, 0. 34). Duration of school enrollment was associated with increased antibody titer, with each month being associated with a 0. 15 unit increase in OD titer (95 % CI: 0. 14, 0. 16). Stunting was associated with lower COVID-19 titers among unvaccinated children (-0. 10, 95 % CI: -0. 21,0. 004), but not among vaccinated children. Stunted children may have poorer immune responses to natural infection, but vaccination can overcome this deficit. Population-wide follow-up vaccination may be beneficial, particularly prior to school entry and for stunted children to reduce the risk of natural infection.
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| Concepts | Keywords |
|---|---|
| Brazil | Antibody response |
| Month | Cohort study |
| Poorer | COVID-19 vaccination |
| Vaccinated | Infectious disease epidemiology |
| Vaccine efficacy |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | nutritional status |
| disease | MESH | Stunting |
| disease | MESH | infection |
| disease | MESH | Infectious disease |
| pathway | REACTOME | Infectious disease |