Publication date: Feb 10, 2025

Elevated concentrations of IL-10 have been detected in coronavirus disease (COVID-19) patients and are a possible disease severity marker. Single nucleotide variants (SNVs) and their haplotypes can be associated with differences in IL-10 levels and with viral disease susceptibility. Evaluate the associations of SNVs and their haplotypes in Brazilian patients with COVID-19 severity and outcome. In this cross-sectional and case-control study, the patients were selected from the University Hospital of State University of Londrina (HU-UEL) (n = 367) and were subdivided into mild (n = 165), moderate (n = 72) and severe (n = 130) groups. The DNA samples of the participants were subjected to real-time PCR for the detection of rs1800896 (A>G), rs1800871 (C>T) and rs1800872 (C>A) genotypes. The haplotypes were inferred with PHASE v2. 1.1. The severe cases of COVID-19 were independently associated with the GG genotype (rs1800896) (P = 0. 038, OR 2. 522, 95 % CI 1. 053-6. 038) as well as with the GCC haplotype in homozygosity (P = 0. 037, OR 2. 767, 95 % CI 1. 065-7. 191). These results showed that the GG genotype of rs1800896 or the GCC haplotype are associated with COVID-19 severity in Brazilian patients.

Semantics

Original Article