RSV-Bacterial Co-Infection Is Associated With Increased Illness Severity in Hospitalized Children – Results From a Prospective Sentinel Surveillance Study.

Publication date: Feb 01, 2025

During the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects the disease severity. We aimed to understand the relationship between RSV-bacterial co-infections and clinical severity since the RSV seasonality change after COVID-19 pandemic. We conducted a prospective, sentinel surveillance study at 20 sites in Portugal in children under 2 years hospitalized with RSV, between April 21 and January 23. Effect of co-infection with potentially pathogenic bacteria (PPB) on the length of hospitalization and disease severity was investigated using multivariate linear and log-binomial regression models. Among 678 RSV hospitalizations, 67. 4% occurred in children under 6 months and 15. 3% in preterm; 20. 4% tested positive for PPB; median length of hospitalization was 5 days (IQR: 3-7days). Children coinfected with PPB had a higher rate of ICU admission (29. 7% vs. 3. 5%, p 

Concepts Keywords
Autumn acute respiratory infection
Bacterial Bacterial Infections
Hospitalizations Child, Preschool
Iqr children
Pandemic co‐infections
Coinfection
Female
Hospitalization
Humans
Infant
Infant, Newborn
Male
Portugal
Prospective Studies
RSV
Sentinel Surveillance

Semantics

Type Source Name
disease MESH Co-Infection
disease MESH COVID-19 pandemic
disease IDO bacteria
disease MESH infection
disease MESH Bacterial Infections
disease MESH Respiratory Syncytial Virus Infections

Original Article

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