Publication date: Feb 08, 2025
AA amyloidosis is a rare renal complication of WaldenstrcF6m’s macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL). A 66-year-old man with WM/LPL presented with nephrotic syndrome. A renal biopsy showed AA amyloidosis. Chemotherapy resulted in the remission of hematologic and nephrotic syndromes. Two years into follow-up, he became infected with COVID-19 and had massive proteinuria, despite no relapse of WM/LPL. A second renal biopsy confirmed a diagnosis of AA amyloidosis. However, increased prednisolone did not improve proteinuria. The patient ultimately died of cryptococcal meningitis. This case highlights the diverse spectrum of renal involvement in monoclonal IgM-secreting diseases and difficulty in managing fatal complications.
| Concepts | Keywords |
|---|---|
| Amyloidosis | Covid19 |
| Biopsy | monoclonal IgM-secreting disease |
| Old | nephrotic syndrome |
| Prednisolone | prednisolone |
| Renal |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Macroglobulinemia |
| disease | MESH | Lymphoma |
| disease | MESH | AA Amyloidosis |
| disease | MESH | nephrotic syndrome |
| disease | MESH | COVID-19 |
| disease | MESH | proteinuria |
| disease | MESH | relapse |
| drug | DRUGBANK | Prednisolone |
| disease | MESH | cryptococcal meningitis |
| disease | MESH | complications |