Publication date: Feb 13, 2025

Persistent SARS-CoV-2 infections have been hypothesized to play a key role in the emergence of variants of concern. However, the factors determining which individuals are at risk and their viral molecular signatures during infection remain poorly understood. Using the extensive COVID-19 surveillance database in Denmark, comprising over 700,000 genomes, we identified 303 persistent infections and, critically, linked them to health and sociodemographic data. Our analysis confirms the hypothesis that immunocompromised individuals are at the highest risk of experiencing persistent infections. Other disease groups associated with mortality, such as diabetes, showed no such associations. Among these persistent infections, the viral sequences exhibited signs of diversifying selection, with recurrent mutations linked to treatment resistance. Our findings suggest that immunosuppression plays a key role in the emergence of novelty in persistent infections.

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