9-aminominocycline potentiates the efficacy of EIDD-1931 and PF-332 by targeting the papain like protease enzyme of SARS-CoV-2.

Publication date: Feb 15, 2025

Concepts	Keywords
Chymotrypsin	Antiviral Agents
Host	Antiviral Agents
Promising	Coronavirus 3C Proteases
Viral	Coronavirus 3C Proteases
	Coronavirus Papain-Like Proteases
	Coronavirus Papain-Like Proteases
	COVID-19 Drug Treatment
	Drug Synergism
	Enzyme kinetics
	Humans
	Hydroxylamines
	Hydroxylamines
	Molecular Docking Simulation
	papain-like protease, SARS-CoV-2
	PLpro inhibitor
	Protease Inhibitors
	Protease Inhibitors
	Replication
	SARS-CoV-2
	SARS-CoV-2
	Virus Replication

Type	Source	Name
drug	DRUGBANK	Papain
disease	IDO	replication
disease	MESH	COVID-19
pathway	KEGG	Viral replication
disease	IDO	host
disease	IDO	immune response
drug	DRUGBANK	Minocycline
disease	IDO	site
disease	MESH	Mody2
disease	MESH	infections
disease	IDO	protein
drug	DRUGBANK	Ritonavir
disease	MESH	sid
drug	DRUGBANK	Coenzyme M
drug	DRUGBANK	Ebselen
drug	DRUGBANK	Guanine
pathway	REACTOME	Deubiquitination
disease	IDO	process
disease	MESH	viral infection
disease	IDO	production
disease	MESH	cytokine storm
disease	MESH	hepatitis
drug	DRUGBANK	Simeprevir
drug	DRUGBANK	Vaniprevir
drug	DRUGBANK	Paritaprevir
drug	DRUGBANK	Grazoprevir
disease	MESH	adverse drug reactions
drug	DRUGBANK	Aniline
drug	DRUGBANK	Tetracycline
drug	DRUGBANK	Doxycycline
drug	DRUGBANK	Tigecycline
drug	DRUGBANK	Glycine
drug	DRUGBANK	Dimethyl sulfoxide
disease	IDO	cell
disease	IDO	infection
disease	MESH	Viral load
disease	MESH	lung adenocarcinoma
drug	DRUGBANK	Amino acids
disease	IDO	algorithm
disease	IDO	assay
disease	IDO	bacteria
disease	MESH	Crimean Congo hemorrhagic fever
disease	MESH	cancer
disease	MESH	autoimmune diseases
disease	MESH	rheumatoid arthritis
pathway	KEGG	Rheumatoid arthritis
disease	MESH	inflammatory bowel diseases
disease	MESH	complications
drug	DRUGBANK	Edetic Acid
drug	DRUGBANK	Phosphate ion
drug	DRUGBANK	Methylergometrine
disease	IDO	facility
drug	DRUGBANK	Medical air
drug	DRUGBANK	Calusterone
drug	DRUGBANK	Aspartame
drug	DRUGBANK	Water
disease	MESH	AIDS
disease	MESH	Mody
drug	DRUGBANK	Chymotrypsin
pathway	REACTOME	Immune System
disease	MESH	immune diseases
disease	MESH	death
drug	DRUGBANK	Nonoxynol-9
pathway	REACTOME	Reproduction

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