The Current Status of Virtual Autopsy Using Combined Imaging Modalities: A Scoping Review.

Publication date: Jan 25, 2025

Background/Objectives: Virtual autopsy (virtopsy) is a new domain of research for interdisciplinary teams of radiologists and forensic specialists. This scoping review aims to underline the current state-of-the-art research using combined imaging modalities. Methods: We searched the PubMed database using the term virtopsy for articles that are available in free full text, indexed in the Medline Database, and published in English. The query returned 49 articles on this subject that have been published since 2002. Results: The main imaging modalities used for postmortem imaging were computed tomography (PMCT), angiography (PMCTA), magnetic resonance imaging (PMMRI), and ultrasonography (PMUS). PMCT is highly effective for detecting complex osseous injuries, tracing bullet trajectories, or identifying characteristic findings in drowning cases. PMCTA is valuable for evaluating vascular lesions, particularly in natural death cases. PMMRI is superior in analyzing soft tissues, including brain and spinal structures, cerebrospinal fluid, microbleeds, and laryngohyoid lesions, and identifying cardiomyopathies in young individuals. PMUS serves as an alternative, and its portability also allows for use in forensic settings. One specific situation observed was the increased number of studies published about virtopsy during the COVID-19 pandemic. Another aspect is the increased focus on this alternative to conventional autopsy in the regions where maneuvering of the deceased is limited according to cultural and social customs. Conclusions: We underline the advantages and limitations of each imaging modality used for virtopsy. Further studies need to be developed in order to gather supplementary data regarding the use of these imaging modalities in the new era of artificial intelligence in medicine.

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Concepts Keywords
Autopsy alternative non-clinical autopsy
Cardiomyopathies postmortem imaging
English virtopsy
Radiologists
Valuable

Semantics

Type Source Name
disease MESH death
disease MESH cardiomyopathies
disease MESH COVID-19 pandemic
drug DRUGBANK Coenzyme M
drug DRUGBANK Sulpiride
disease MESH infection
drug DRUGBANK Medical air
disease MESH hemorrhages
disease MESH pleural effusions
disease MESH intracranial gas
disease IDO history
disease MESH cannabis abuse
drug DRUGBANK Scopolamine
disease MESH cerebral edema
disease MESH edema
disease MESH cardiomegaly
disease IDO blood
disease MESH asphyxia
disease MESH fat embolism
disease MESH abnormalities
disease MESH sepsis
disease MESH septic shock
disease IDO process
drug DRUGBANK Acetate ion
drug DRUGBANK Water
drug DRUGBANK Polyethylene glycol
disease MESH liver steatosis
disease MESH embolism
drug DRUGBANK Piroxicam
drug DRUGBANK Ethanol
disease MESH infant deaths
drug DRUGBANK Gold
disease MESH hematomas
disease MESH rigor mortis
disease MESH abdominal aortic aneurysms
disease MESH pericardial tamponade
disease MESH subphrenic abscesses
disease MESH respiratory failure
disease MESH critically ill
disease MESH infection transmission
drug DRUGBANK Etoperidone
disease MESH fetal demise
disease MESH sudden death
drug DRUGBANK Spinosad
disease IDO algorithm
disease MESH foreign bodies
disease MESH neurodegenerative diseases
pathway REACTOME Neurodegenerative Diseases
drug DRUGBANK Isoxaflutole
disease MESH spotting
disease IDO quality
disease MESH fatal outcome

Original Article

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