Estimates of SARS-CoV-2 Infections and Population Immunity After the COVID-19 Pandemic in Austria: Analysis of National Wastewater Data.

Publication date: Feb 18, 2025

Postpandemic surveillance data on coronavirus disease 2019 (COVID-19) infections may help inform future public health policies regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, vaccinations, or other COVID-19 measures. We estimate the total SARS-CoV-2 infections in Austria after the end of the pandemic from wastewater data and utilize these estimates to calculate the average national levels of SARS-CoV-2 infection protection and COVID-19 death protection. We estimated the total SARS-CoV-2 infections in Austria after the end of the pandemic (5 May 2023, per World Health Organization) up to May 2024 from wastewater data using a previously published model. These estimates were used in an agent-based model (ABM) to estimate average national levels of SARS-CoV-2 infection protection and COVID-19 death protection, based on waning immunity estimates of infections and vaccination in previous literature. We estimate approximately 3. 2 million infections between 6 May 2023 and 23 May 2024, with a total of 17. 8 million infections following 12 May 2020. The ABM estimates that the national average death protection was approximately 82% higher in May 2024 than before the pandemic. This represents a relative decrease of 8% since May 2023. It also shows that 95% of people in Austria were infected with SARS-CoV-2 at least once by May 2024. National infection protection remained relatively low after the onset of Omicron. These findings should be considered for public health decisions on SARS-CoV-2 testing practices and vaccine booster administrations.

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Concepts Keywords
Austria COVID-19
Coronavirus immunization
Postpandemic nationwide
Vaccination SARS-CoV-2
wastewater

Semantics

Type Source Name
disease MESH SARS-CoV-2 Infections
disease MESH infections
pathway REACTOME SARS-CoV-2 Infection
disease MESH death
disease IDO infection
disease MESH Infectious Diseases
disease IDO facility
disease MESH Emergency
pathway REACTOME Reproduction
drug DRUGBANK Isoxaflutole
drug DRUGBANK Coenzyme M
disease MESH reinfection
disease IDO susceptibility
drug DRUGBANK Ranitidine
drug DRUGBANK Stavudine
disease MESH uncertainty
disease IDO virulence
disease IDO contact tracing
disease MESH severe acute respiratory syndrome
drug DRUGBANK Trestolone
drug DRUGBANK Water
disease IDO blood
disease MESH syndrome
disease MESH healthcare associated infections

Original Article

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