Publication date: May 22, 2025

Background/Objectives: Rapid and accurate assessment of lung diseases, like pneumonia, is critical for effective clinical decision-making, particularly during pandemics when disease progression can be severe. Early diagnosis plays a crucial role in preventing complications, necessitating the development of fast and efficient AI-based models for automated severity assessment. Methods: In this study, we introduce a novel approach that leverages VMamba, a state-of-the-art vision model based on the VisualStateSpace (VSS) framework and 2D-Selective-Scan (SS2D) spatial scanning, to enhance lung severity prediction. Integrated in a parallel multi-image regions approach, VMamba effectively captures global and local contextual features through structured state-space modeling, improving feature representation and robustness in medical image analysis. Additionally, we integrate a segmented lung replacement augmentation strategy to enhance data diversity and improve model generalization. The proposed method is trained on the RALO and COVID-19 datasets and compared against state-of-the-art models. Results: Experimental results demonstrate that our approach achieves superior performance, outperforming existing techniques in prediction accuracy and robustness. Key evaluation metrics, including Mean Absolute Error (MAE) and Pearson Correlation (PC), confirm the model’s effectiveness, while the incorporation of segmented lung replacement augmentation further enhances adaptability to diverse lung conditions. Conclusions: These findings highlight the potential of our method for reliable and immediate clinical applications in lung infection assessment.

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