Publication date: May 27, 2025
This study introduces a fiber-optic sensor functionalized with a sensing probe for SARS-CoV-2 RNA detection. The sensor employs a microsphere design at the sensor’s tip, enhanced with a gold layer and oligonucleotide probes, to achieve high sensitivity and specificity. Utilizing optical interference, the system enables near real-time monitoring of viral RNA at concentrations as low as 10 M. While the sensor’s sensitivity is lower than that of the RT-PCR, it excels in speed, portability, and scalability, making it suitable for point-of-care diagnostics, environmental monitoring, and large-scale screening. The integration of fiber-optic sensors with advanced analytical systems further enhances their utility in preventing virus transmission and contamination, highlighting their role in global efforts to combat infectious diseases.
| Concepts | Keywords |
|---|---|
| 10m | fiber‐optic sensor |
| Biophotonics | optical detection |
| Low | viral detection |
| Optical | |
| Viral |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Gold |
| disease | IDO | role |
| disease | MESH | infectious diseases |