Publication date: May 30, 2025

COVID-19 can affect hematological and biochemical parameters, potentially altering platelet function. This study aimed to evaluate the long-term effects of COVID-19 on the quality of platelet concentrates (PCs) collected from donors with a history of infection. Twenty PCs were selected from male donors who had recovered from COVID-19. Donors were divided into two groups: control (recovered more than 6 months ago) and case (recovered between 1 and 3 months ago). Research variables, including metabolic and oxidative parameters, were evaluated. Platelet aggregation was also measured at various time points during PC storage. Both groups showed significant decreases in glucose and pH, and increases in lactate, LDH activity, and ROS during storage (p  0. 05). PC from donors recently recovered from COVID-19 exhibited a decline in aggregation in response to both collagen and arachidonic acid; however, the reduction in arachidonic acid-induced aggregation was particularly significant, indicating a selective impairment in platelet function following infection. Biochemical markers did not show significant differences between groups. Further studies with larger cohorts and clinical efficacy assessments are essential to comprehensively evaluate the safety and effectiveness of transfusing PC from donors recently recovered from COVID-19.

Semantics

Original Article