Publication date: Apr 27, 2025
Over the past 3 years, several kidney complications in children with severe involvement by SARS-CoV-2 have been described. However, literature data are still lacking regarding possible kidney injury in children with paucisymptomatic SARS-CoV-2 infection. Thus, we retrospectively evaluated renal function in those patients. Children between 3 and 18 years, without any renal disease, with previous paucisymptomatic SARS-CoV-2 infection from May 2020 to March 2022, were recruited at our post-COVID-19 outpatient clinic. We retrospectively collected: Glomerular filtration rate, Fractional-excretion-of-sodium (FENa), tubular-reabsorption-of-phosphate (TRP), calcium-creatinine-urine ratio (CaU/CrU); proteinuria/m/day and microhematuria by urine cytofluorometry. A total of 148 children were enrolled after a median period of 3 (IQR 6) months after infection. Twenty-six patients (17. 6%) had reduced GFR, fifty (33. 9%) had hyperfiltration, eleven (7. 4%) had abnormal FENa and/or TRP, twenty-two (14. 9%) had hypercalciuria, seventy-eight (52. 7%) had pathological daily proteinuria. Microhematuria was found in sixteen (10. 9%) subjects. Hyperfiltration was more prevalent among males (38. 9% vs. 22. 4%, p = 0. 027); CaU/CrU [median 0. 08 (IQR 0. 09) vs. 0. 13 (IQR 0. 13) p = 0. 003] was significantly higher in females. Our data suggest that SARS-CoV-2 could determine, in a significant proportion of children, kidney damage characterized by hyperfiltration, proteinuria, and hematuria, warranting strict follow-up in these patients.
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| Concepts | Keywords |
|---|---|
| Kidney | children |
| Males | COVID-19 |
| Microhematuria | kidney |
| Outpatient | proteinuria |
| SARS-CoV-2 |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Proteinuria |
| disease | MESH | Infection |
| disease | MESH | complications |
| disease | MESH | SARS-CoV-2 infection |
| pathway | REACTOME | SARS-CoV-2 Infection |
| drug | DRUGBANK | Phosphate ion |
| drug | DRUGBANK | L-Tryptophan |
| drug | DRUGBANK | Calcium |
| drug | DRUGBANK | Creatinine |
| disease | MESH | hypercalciuria |
| disease | MESH | hematuria |
| drug | DRUGBANK | Coenzyme M |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | interstitial pneumonia |
| disease | MESH | syndrome |
| disease | MESH | heart failure |
| disease | MESH | abnormalities |
| disease | MESH | encephalopathy |
| disease | MESH | vasculitis |
| disease | MESH | optic neuritis |
| disease | MESH | gastroenteritis |
| disease | MESH | colitis |
| disease | MESH | acute kidney injury |
| disease | MESH | nephrotic syndrome |
| disease | MESH | relapses |
| disease | MESH | glomerulonephritis |
| disease | MESH | hemolytic uremic syndrome |
| disease | MESH | critically ill |
| disease | MESH | kidney diseases |
| disease | MESH | rhinitis |
| disease | MESH | arthralgias |