ADDRESS-LC Study of Long COVID Initiated, Phase 4 Trial Testing IVIg Transition to Efgartigimod, Lack of Rebound Effect Seen in Ozanimod

ADDRESS-LC Study of Long COVID Initiated, Phase 4 Trial Testing IVIg Transition to Efgartigimod, Lack of Rebound Effect Seen in Ozanimod

Publication date: Jun 01, 2025

The newly initiated study is a randomized, placebo-controlled trial consisting of 200 patients with Long COVID who have cognitive impairment sequelae and fatigue for at least 3 months. Rebound effect, referring to clinical and/or radiological worsening of disease activity, is a well-documented concern with certain disease-modifying therapies for MS, particularly when they are discontinued or switched. Efgartigimod, originally approved for myasthenia gravis, became the first and only neonatal Fc receptor (FcRn) blocker approved for the treatment of CIDP in 2024. While relapse rates were slightly higher among women, these findings were consistent with previously reported rates. WATCH TIME: 4 minutesWelcome to this special edition of Neurology News Network. Thanks for watching.

Concepts Keywords
Daybreak Address
Insulin Covid
Recruitment Efgartigimod
Sclerosis Initiated
Ivig
Lc
Long
Ozanimod
Phase
Rebound
Testing
Transition
Treatment
Trial
Worsening

Semantics

Type Source Name
drug DRUGBANK Tropicamide
disease MESH myasthenia gravis
disease MESH CIDP
disease MESH polyneuropathy
disease MESH sequelae
disease MESH cognitive impairment
disease MESH Long COVID
drug DRUGBANK Immune Globulin Human
drug DRUGBANK Ozanimod
drug DRUGBANK Coenzyme M
drug DRUGBANK Gadolinium
disease MESH multiple sclerosis
disease MESH relapse

Original Article

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