Publication date: Jun 02, 2025

Viruses are a major global health concern, particularly in impoverished countries. Human communities are exposed to numerous viral infections due to various anthropological activities; many diseases manifest as outbreaks. Finding new viruses in these circumstances is crucial for choosing preventative and therapeutic measures. Over the past 15 years, high-throughput DNA sequencing methodology (NGS) has quickly changed, and new techniques are constantly being made available for purchase. The expansion and commercialization of next-generation sequencers have significantly altered the discovery of the virus. A variety of genetic material, from a very diverse mixture with excellent sensitivity, may be produced by these highly parallel sequencing devices. Furthermore, because these phases are sequence-independent, they are advantageous instruments for viral discovery. To detect SARS-CoV-2, the sequencing of the next generation is used to analyze the upcoming infection and related diseases. We examine the development of sequencing, NGS technologies accessible today, and commonly utilized viral enrichment approaches in this study.

Semantics

Original Article