Publication date: Jun 02, 2025
The emergence of glomerular diseases following COVID-19 vaccination, particularly with mRNA vaccines, has sparked significant interest in the scientific community. We present the genetic analysis of a case involving a 51-year-old female who developed C3 glomerulopathy following her 3 dose of the mRNA-1273 (Moderna) COVID-19 vaccine. Through comprehensive whole-genome exome sequencing, we identified a missense mutation in the SLC12A3 gene, along with other genetic variations, which may provide insights into the molecular mechanisms underpinning vaccine-associated glomerulopathies. This case underscores the importance of exploring genetic predispositions when encountering adverse reactions to mRNA vaccines, particularly those affecting the complement pathway and glomerulopathies.
| Concepts | Keywords |
|---|---|
| Genetical | Acute |
| Kidney | Analysis |
| Moderna | Covid |
| Vaccines | Emergence |
| Genetic | |
| Genetical | |
| Glomerular | |
| Glomerulopathies | |
| Glomerulopathy | |
| Injury | |
| Kidney | |
| Moderna | |
| Mrna | |
| Vaccine | |
| Vaccines |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | acute kidney injury |
| disease | MESH | COVID-19 |