Publication date: Jun 05, 2025
Apparently, mRNA vaccines have played a pivotal role in curbing the further spread of COVID-19. However, their deployment has been accompanied by reports of adverse events (AEs), including cardiovascular and neurological symptoms. The comprehensive review proposes a conceptual framework to better characterize AEs, elucidate the underlying mechanisms, and outline therapeutic strategies. It also profiles AEs into a three-axe mechanism classification: host susceptibility, delivery system interactions, and mRNA component immunogenicity, thereby advancing current understanding of their etiology. Finally, the analysis integrates these axes with critical perspectives – mRNA molecular design, platform-specific toxicity, and human nature – to provide a comprehensive roadmap for addressing above issues.
| Concepts | Keywords |
|---|---|
| Axe | Adverse event |
| Host | Mechanism |
| Mrna | mRNA vaccine |
| Roadmap | |
| Vaccine |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | role |
| disease | MESH | COVID-19 |
| drug | DRUGBANK | Tropicamide |
| disease | IDO | host |
| disease | IDO | susceptibility |
| disease | MESH | etiology |