Publication date: Dec 01, 2025

The long-term cardiovascular (CVD) and mortality risk associated with mild COVID-19 infections in patients on hemodialysis (HD) during the post-Omicron era remains unclear. This study evaluates clinical outcomes in patients on HD following Omicron infection. This retrospective observational study included 462 patients from a single center. All mild COVID-19 cases occurred after January 2022. The first analysis compared patients with prior mild COVID-19 (COVID-19 history [+], n = 63) to those never infected including the observational period (COVID-19 infection [-], n = 286). The second analysis included 392 patients without prior infection, comparing those who acquired mild COVID-19 during follow-up (COVID-19 infection [+]) with those in the COVID-19 infection [-] group. The primary outcome was CVD events. Multivariate analyses assessed COVID-19 infections’s impact on clinical outcomes. After 761 days, 100 CVD events including 51 cardiovascular deaths and 58 non-CVD deaths occurred. The CVD risk did not significantly differ between the COVID-19 history (+) and infection (-) groups (Hazard ration [HR]: 0. 50, 95% confidence interval [CI]: 0. 25-1. 01, p = . 054) as well as non-CVD mortality. In the second analysis, patients with newly acquired COVID-19 did not exhibit a significantly increased risk of CVD (HR: 0. 55, 95% CI: 0. 25-1. 19, p = . 132) or non-CVD mortality. Mild COVID-19 infections does not significantly increase long-term CVD and mortality risk in patients on HD in the post-Omicron era.

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