A review of the sequelae of post Covid-19 with neurological implications (post-viral syndrome).

Publication date: Jul 15, 2025

Post Covid-19 conditions represent a medical challenge; a unified definition is not achieved after 5 years of the Pandemic. The incidence of Post Covid-19 conditions varies, nevertheless the neurological complications represent an important aspect in the spectrums of fields involved. The current perception is that varied manifestations and long-term complications of COVID-19 reflect underlying pathophysiological processes, including inflammatory, immune-mediated, and vascular mechanisms. These mechanisms underscore the complexity of COVID-19’s impact including the nervous system and its potential for lasting effects. A number of symptoms are extremely severe and may also need neurologic attention including fatigue, cognitive disturbances, autonomic symptoms, headache, and sleep disorders. Post Covid-19 conditions are often of chronic nature. Management as in other chronic conditions should rely on the conventional diagnostic measures and management of symptoms irrespective of the temporal relation to the viral infection. To date Post Covid-19 conditions is only accepted as an additional or explanatory diagnosis.

Concepts Keywords
5years COVID-19
Pandemic Humans
Sleep Long covid-19
Vascular Nervous System Diseases
Viral Post Covid-19
Post viral
Post-Acute COVID-19 Syndrome
SARS-CoV-2

Semantics

Type Source Name
disease MESH sequelae
disease MESH Covid-19
disease MESH syndrome
disease MESH sleep disorders
disease MESH chronic conditions
disease MESH viral infection
disease MESH Long Covid
disease MESH Nervous System Diseases

Original Article

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