Publication date: Jun 13, 2025
Long COVID is a condition characterized by persistent unexplained symptoms following COVID-19 infection. These symptoms are not related to another disease or organ damage and are similar to those in fibromyalgia and myslgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The similar clinical and pathophysiological features and management of long COVID, fibromyalgia and ME/CFS are explored from the unifying framework of central sensitivity syndromes. The article is based on a literature search utilizing PubMed for content published between 2021 and 1 May 2025, using search terms: long COVID, long COVID syndrome, post-COVID-19, post-acute SARS-CoV-2, fibromyalgia, ME/CFS, post-exertional malaise and central sensitization. Once long COVID is redefined to exclude patients with well-defined organ disease, it fits best as a model of central sensitization. Long COVID is a single syndrome, rather than many distinct diseases. Optimal management of long COVID and similar central sensitivity syndromes should include personalized care with a primary care led-multidisciplinary team.
Concepts | Keywords |
---|---|
Covid | brain imaging |
Expert | central sensitization |
Fibromyalgia | chronic |
Organ | fibromyalgia |
Long COVID | |
widespread pain |
Semantics
Type | Source | Name |
---|---|---|
disease | IDO | role |
disease | MESH | central sensitization |
disease | MESH | long COVID |
disease | MESH | fibromyalgia |
disease | MESH | myalgic encephalomyelitis |
disease | MESH | COVID-19 |
disease | MESH | infection |
disease | MESH | encephalomyelitis |
disease | MESH | syndromes |