Changes in Population Immunity to Omicron SARS-CoV-2 Variants and Selected Sarbecoviruses From 2020 to 2023 in Urban Colombo, Sri Lanka.

Publication date: Jul 01, 2025

To understand how the population immunity evolved over time and possible susceptibility of the Sri Lankan population to emerging SARS-CoV-2 variants, we proceeded to evaluate the changes in antibody positivity rates to omicron variants BA. 2.75 and XBB. 1.5 and for selected sarbecoviruses. The haemagglutination test was carried out to determine the presence of antibodies against the RBD of the SARS-CoV-2 omicron variants XBB. 1.5 and BA. 2.75 and the RBD of the sarbecoviruses RaTG13, WIV1, Khosta-2, and SARS-CoV-1, in individuals aged 5-80 years of age in years 2020 (n = 381), 2022 (n = 432), and 2023 (n = 382). The highest positivity rates for BA. 2.75, RaTG13, WIV1, Khosta-2, and SARS-CoV-1 were seen in 2022, with positivity rates significantly declining for many of the viruses except XBB. 1.5 and Khosta-2 by 2023. The positivity rates for Khosta-2 (p 

Concepts Keywords
Lanka Adolescent
Med Adult
Sarbecoviruses Aged
Aged, 80 and over
antibodies
Antibodies, Viral
Antibodies, Viral
Child
Child, Preschool
COVID-19
Female
Humans
Male
Middle Aged
sarbecoviruses
SARS-CoV-2
SARS‐CoV‐2
Sri Lanka
vaccines
Young Adult

Semantics

Type Source Name
disease IDO susceptibility
disease MESH COVID-19

Original Article

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