Burden of disease and seasonal data of children hospitalized due to RSV and Influenza infection before, during and after the COVID-19 pandemic.

Publication date: Jun 30, 2025

We sought to assess the burden of disease of RSV and influenza in hospitalized children in the context of the COVID-19 pandemic and its preventive measures in the winter seasons from 2019/2020 to 2023/2024. We compared both diseases by means of a retrospective, single-center study from October 1, 2019, to April 30, 2024, including infants and children up to 18 years hospitalized due to an RSV and/or influenza infection at Clinic Donaustadt, Vienna. Infection had to be proven by polymerase chain reaction or antigen test. By evaluating each single hospital course, we analysed seasonality, detailed patient characteristics and parameters of disease severity. Overall, there were 894 children hospitalized, 561 due to RSV and 314 due to influenza, 19 due to both viruses. Cases with RSV infection were younger of age (mean: 16. 5 vs. 58. 1 months; p 

Concepts Keywords
Clinic Adolescent
Influenza Austria
Vienna Child
Winter Child, Preschool
Cost of Illness
COVID-19
COVID-19 pandemic
Female
Hospitalization
Humans
Infant
Influenza virus
Influenza, Human
Male
Morbidity and mortality
Pandemics
Prophylaxis
Respiratory syncytial virus
Retrospective Studies
SARS-CoV-2
Seasons

Semantics

Type Source Name
pathway REACTOME Influenza Infection
disease MESH COVID-19 pandemic
disease MESH influenza
disease MESH Infection
disease MESH RSV infection
disease MESH Morbidity

Original Article

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