Publication date: Jul 01, 2025
Newborns depend on the transfer of IgG across the placenta to acquire protection against pathogens. We assessed the placental transfer of SARS-CoV-2 antibodies, primarily derived from infection, from seropositive pregnant women enrolled in a pregnancy cohort in Kilifi, Kenya. The study was nested within a prospective observational multi-country cohort study. All available paired maternal delivery and cord blood samples were selected. Maternal sera were tested for SARS-CoV-2 receptor binding domain (RBD) IgM/IgG total antibodies using the Wantai assay. For positive samples, maternal and corresponding cord blood samples were tested for SARS-CoV-2 IgG antibodies against the spike (anti-spike) and nucleocapsid proteins (anti-NCP) using ELISA kits from Euroimmun. A total of 492 (56. 1%) out of 877 maternal delivery samples were positive for RBD IgM/IgG total antibodies. Of these, 416 (84. 6%) were seropositive for either anti-NCP IgG, anti-spike IgG antibodies or both. A total of 412 out of 496 (83%) cord blood samples tested positive for either anti-NCP or anti-spike antibodies. The geometric mean ratio was 1. 04 (95% CI: 0. 90, 1. 21), indicating no significant difference between the anti-spike IgG concentration in cord and maternal blood samples. The log-transformed maternal and cord blood anti-spike IgG concentrations showed a weak positive correlation (r = 0. 364, n = 496, p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | infection |
| disease | IDO | country |
| disease | IDO | assay |
| disease | IDO | blood |
| disease | MESH | Infectious Diseases |
| pathway | REACTOME | Reproduction |
| drug | DRUGBANK | Indoleacetic acid |
| disease | MESH | COVID-19 |
| disease | MESH | Pregnancy Complications Infectious |