Comparison between simulated scenarios and Swedish COVID-19 cases throughout the pandemic.

Publication date: Jul 02, 2025

This study assesses the accuracy of COVID-19 scenarios for new infections produced by the Swedish Public Health Agency (PHAS) from December 1, 2020, to March 20, 2023. We introduce a Similarity Error ([Formula: see text]), which evaluates the dissimilarity between simulated and observed case time series using the following attributes: area under the curves, peak timings, and growth/decline rates before and after peaks. Rather than using an arbitrary cut-off, we used a threshold determined through Receiver Operating Characteristic (ROC) analysis, with performance evaluated using the Area Under the Curve (AUC), based on true positives identified by visual inspection for categorization. To further evaluate [Formula: see text]’s effectiveness, we conducted a sensitivity analysis across the full range of possible threshold values within the unit interval. Applying [Formula: see text] with an optimal threshold determined through ROC-analysis 7 rounds out of 11 rounds were classified as having one or more similar scenarios, including the 6 rounds identified by visual inspection. Our findings indicate that, despite the challenges of a rapidly evolving epidemic, PHAS delivered simulations that reflected real-world trends in most of the rounds.

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Concepts Keywords
Covid Area Under Curve
December Computer Simulation
Pandemic COVID-19
Swedish COVID-19
Humans
Pandemics
ROC Curve
SARS-CoV-2
Scenario analysis
Simulation similarity
Sweden
Time series comparison

Semantics

Type Source Name
disease MESH COVID-19
disease MESH infections
drug DRUGBANK Saquinavir
drug DRUGBANK Serine
disease IDO intervention
drug DRUGBANK Coenzyme M
disease IDO algorithm
drug DRUGBANK L-Aspartic Acid
disease MESH uncertainty
drug DRUGBANK Huperzine B
disease MESH influenza
disease MESH emergency
pathway REACTOME Reproduction

Original Article

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